We just released system update 1 for ZENworks Configuration Management, customers that have ZCM 10.0.1 installed will be able to update using the system update process described in the documentation.
If your server is still at 10.0.0, you will need to get to 10.0.1 first, TID 3407754 describes how to upgrade to 10.0.1 if your server is still at 10.0.0.
In many environments the primary server(s) won't be able to get direct access to the internat and will need to go through an internet proxy. If you are in such an environment, have a look at TID 3087025, this describes how to configure ZCM to get the patches through a proxy server.
For the people that want to know what got fixed, we will be updating TID 3486285 with the details on what got fixed in this patch.