iFolder synchronizes individual files or the changed portions of individual files; it does not synchronize files as a set. If you have a database file that is implemented as a collection of linked files, do not try to synchronize them in an iFolder.
Do not try to synchronize your GroupWise data by making the GroupWise archive, cache, or remote directories into iFolders. If you do this, the GroupWise data files become corrupted after synchronizing the file a few times. GroupWise needs the files in the archive to be maintained as a set of files.